Flavonoid Rutin Presented Anti-Glioblastoma Activity Related to the Modulation of Onco miRNA-125b Expression and STAT3 Signaling and Impact on Microglia Inflammatory Profile

Flavonoid Rutin Presented Anti-Glioblastoma Activity Related to the Modulation of Onco miRNA-125b Expression and STAT3 Signaling and Impact on Microglia Inflammatory Profile

Glioblastoma (GBM) is the most aggressive and treatment-resistant brain tumor. In the GBM microenvironment, interaction with microglia is associated with the dysregulation of cytokines, chemokines, and miRNAs, contributing to angiogenesis, proliferation, anti-apoptosis, and chemoresistance. The flav...

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Bibliographic Details
Main Authors: Irlã Santos Lima, Érica Novaes Soares, Carolina Kymie Vasques Nonaka, Bruno Solano de Freitas Souza, Balbino Lino dos Santos, Silvia Lima Costa
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:Brain Sciences
Subjects:
glioblastoma
miRNA-125b
STAT3
inflammatory cytokines
rutin
Online Access:https://www.mdpi.com/2076-3425/14/1/90

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