Allosteric inhibition of SHP2 uncovers aberrant TLR7 trafficking in aggravating psoriasis

Allosteric inhibition of SHP2 uncovers aberrant TLR7 trafficking in aggravating psoriasis

Abstract Psoriasis is a complex chronic inflammatory skin disease with unclear molecular mechanisms. We found that the Src homology‐2 domain‐containing protein tyrosine phosphatase‐2 (SHP2) was highly expressed in both psoriatic patients and imiquimod (IMQ)‐induced psoriasis‐like mice. Also, the SHP...

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Bibliographic Details
Main Authors: Yuyu Zhu, Zhigui Wu, Wei Yan, Fenli Shao, Bowen Ke, Xian Jiang, Jian Gao, Wenjie Guo, Yuping Lai, Hongyue Ma, Dijun Chen, Qiang Xu, Yang Sun
Format: Article
Language:English
Published: Springer Nature 2022-03-01
Series:EMBO Molecular Medicine
Subjects:
psoriasis
PTPN11
scRNA‐seq
therapeutic target
TLR7
Online Access:https://doi.org/10.15252/emmm.202114455

Internet

https://doi.org/10.15252/emmm.202114455

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