Bone mineral: A trojan horse for bone cancers. Efficient mitochondria targeted delivery and tumor eradication with nano hydroxyapatite containing doxorubicin

Bone mineral: A trojan horse for bone cancers. Efficient mitochondria targeted delivery and tumor eradication with nano hydroxyapatite containing doxorubicin

Efficient systemic pharmacological treatment of solid tumors is hampered by inadequate tumor concentration of cytostatics necessitating development of smart local drug delivery systems. To overcome this, we demonstrate that doxorubicin (DOX), a cornerstone drug used for osteosarcoma treatment, shows...

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Bibliographic Details
Main Authors: Yang Liu, Aftab Nadeem, Sujeesh Sebastian, Martin A. Olsson, Sun N. Wai, Emelie Styring, Jacob Engellau, Hanna Isaksson, Magnus Tägil, Lars Lidgren, Deepak Bushan Raina
Format: Article
Language:English
Published: Elsevier 2022-03-01
Series:Materials Today Bio
Subjects:
Drug delivery
Nano and micro hydroxyapatite
Doxorubicin
Solid tumor
Osteosarcoma
Online Access:http://www.sciencedirect.com/science/article/pii/S2590006422000254

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http://www.sciencedirect.com/science/article/pii/S2590006422000254

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