Transmission of tauopathy strains is independent of their isoform composition

Although normal human brains express 6 tau isoforms in equal ratio with 3 or 4 microtubule-binding repeat domains (3R and 4R), tau inclusions from different human tauopathy brains, now considered as different strains, have distinct isoform compositions and strain properties and the relationship betw...

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التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Zhuohao He, Jennifer D. McBride, Hong Xu, Lakshmi Changolkar, Soo-jung Kim, Bin Zhang, Sneha Narasimhan, Garrett S. Gibbons, Jing L. Guo, Michael Kozak, Gerard D. Schellenberg, John Q. Trojanowski, Virginia M. -Y. Lee
التنسيق: مقال
اللغة:English
منشور في: Nature Portfolio 2020-01-01
سلاسل:Nature Communications
الوصول للمادة أونلاين:https://doi.org/10.1038/s41467-019-13787-x