Transmission of tauopathy strains is independent of their isoform composition

Although normal human brains express 6 tau isoforms in equal ratio with 3 or 4 microtubule-binding repeat domains (3R and 4R), tau inclusions from different human tauopathy brains, now considered as different strains, have distinct isoform compositions and strain properties and the relationship betw...

Descripció completa

Dades bibliogràfiques
Autors principals: Zhuohao He, Jennifer D. McBride, Hong Xu, Lakshmi Changolkar, Soo-jung Kim, Bin Zhang, Sneha Narasimhan, Garrett S. Gibbons, Jing L. Guo, Michael Kozak, Gerard D. Schellenberg, John Q. Trojanowski, Virginia M. -Y. Lee
Format: Article
Idioma:English
Publicat: Nature Portfolio 2020-01-01
Col·lecció:Nature Communications
Accés en línia:https://doi.org/10.1038/s41467-019-13787-x