Novel Auger-Electron-Emitting <sup>191</sup>Pt-Labeled Pyrrole–Imidazole Polyamide Targeting MYCN Increases Cytotoxicity and Cytosolic dsDNA Granules in MYCN-Amplified Neuroblastoma

Novel Auger-Electron-Emitting <sup>191</sup>Pt-Labeled Pyrrole–Imidazole Polyamide Targeting MYCN Increases Cytotoxicity and Cytosolic dsDNA Granules in MYCN-Amplified Neuroblastoma

Auger electrons can cause nanoscale physiochemical damage to specific DNA sites that play a key role in cancer cell survival. Radio-Pt is a promising Auger-electron source for damaging DNA efficiently because of its ability to bind to DNA. Considering that the cancer genome is maintained under abnor...

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Bibliographic Details
Main Authors: Honoka Obata, Atsushi B. Tsuji, Hitomi Sudo, Aya Sugyo, Kaori Hashiya, Hayato Ikeda, Masatoshi Itoh, Katsuyuki Minegishi, Kotaro Nagatsu, Mikako Ogawa, Toshikazu Bando, Hiroshi Sugiyama, Ming-Rong Zhang
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:Pharmaceuticals
Subjects:
platinum-191
Auger electron
MYCN
neuroblastoma
cGAS-STING
interferon
Online Access:https://www.mdpi.com/1424-8247/16/11/1526

Internet

https://www.mdpi.com/1424-8247/16/11/1526

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