Exogenous 8-hydroxydeoxyguanosine attenuates doxorubicin-induced cardiotoxicity by decreasing pyroptosis in H9c2 cardiomyocytes

Exogenous 8-hydroxydeoxyguanosine attenuates doxorubicin-induced cardiotoxicity by decreasing pyroptosis in H9c2 cardiomyocytes

Abstract Doxorubicin (DOX), which is widely used in cancer treatment, can induce cardiomyopathy. One of the main mechanisms whereby DOX induces cardiotoxicity involves pyroptosis through the NLR family pyrin domain containing 3 (NLRP3) inflammasome and gasdermin D (GSDMD). Increased NAPDH oxidase (N...

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Bibliographic Details
Main Authors: Soyoung Hwang, Se-Hee Kim, Kwai Han Yoo, Myung-Hee Chung, Jin Woo Lee, Kuk Hui Son
Format: Article
Language:English
Published: BMC 2022-12-01
Series:BMC Molecular and Cell Biology
Subjects:
Exogenous 8-hydroxydeoxyguanosine
Doxorubicin
Cardiotoxicity
Pyroptosis
Online Access:https://doi.org/10.1186/s12860-022-00454-1

Internet

https://doi.org/10.1186/s12860-022-00454-1

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