Research Progress of CD47-SIRPα Signaling Axis as An Innate Immune Checkpoint in Cancer
Immune checkpoint inhibitors, including those targeting CTLA-4/B7 and PD-1/PD-L1 inhibitory pathways, are now available for clinical use on cancer patients. Other interesting checkpoint inhibitors are currently under the development. CD47 is a protein broadly expressed on the surface of normal cells...
| Main Authors: | , , |
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| Format: | Article |
| Language: | zho |
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Magazine House of Cancer Research on Prevention and Treatment
2018-08-01
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| Series: | Zhongliu Fangzhi Yanjiu |
| Subjects: | |
| Online Access: | http://html.rhhz.net/ZLFZYJ/html/8578.2018.18.0217.htm |
| Summary: | Immune checkpoint inhibitors, including those targeting CTLA-4/B7 and PD-1/PD-L1 inhibitory pathways, are now available for clinical use on cancer patients. Other interesting checkpoint inhibitors are currently under the development. CD47 is a protein broadly expressed on the surface of normal cells and often overexpressed in cancer cells, and its receptor is the myeloid inhibitory immunoreceptor SIRPα. Blocking CD47-SIRPα interactions has been shown to promote the destruction of cancer cells by phagocytes, including macrophages and neutrophils. Furthermore, there is growing evidence that targeting CD47-SIRPα axis may also promote antigen-presenting cell function and thereby stimulate T cell-mediated anti-cancer immunity. In summary, with the clinical studies about CD47-SIRPα checkpoint inhibitors expected within the coming years, this is an exciting and rapidly developing field. |
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| ISSN: | 1000-8578 1000-8578 |