Near-infrared duocarmycin photorelease from a Treg-targeted antibody-drug conjugate improves efficacy of PD-1 blockade in syngeneic murine tumor models

Near-infrared duocarmycin photorelease from a Treg-targeted antibody-drug conjugate improves efficacy of PD-1 blockade in syngeneic murine tumor models

Regulatory T cells (Tregs) play a crucial role in mediating immunosuppression in the tumor microenvironment. Furthermore, Tregs contribute to the lack of efficacy and hyperprogressive disease upon Programmed cell death protein 1 (PD-1) blockade immunotherapy. Thus, Tregs are considered a promising t...

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Bibliographic Details
Main Authors: Hiroshi Fukushima, Aki Furusawa, Seiichiro Takao, Ebaston Thankarajan, Michael P Luciano, Syed Muhammad Usama, Makoto Kano, Shuhei Okuyama, Hiroshi Yamamoto, Motofumi Suzuki, Miyu Kano, Peter L Choyke, Martin J Schnermann, Hisataka Kobayashi
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:OncoImmunology
Subjects:
Antibody-drug conjugate
near-infrared light
PD-1 blockade
photouncaging
regulatory T cell
Online Access:https://www.tandfonline.com/doi/10.1080/2162402X.2024.2370544

Internet

https://www.tandfonline.com/doi/10.1080/2162402X.2024.2370544

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