DNA methylation subtypes guiding prognostic assessment and linking to responses the DNA methyltransferase inhibitor SGI-110 in urothelial carcinoma

DNA methylation subtypes guiding prognostic assessment and linking to responses the DNA methyltransferase inhibitor SGI-110 in urothelial carcinoma

Abstract Background At present, the extent and clinical relevance of epigenetic differences between upper tract urothelial carcinoma (UTUC) and urothelial carcinoma of the bladder (UCB) remain largely unknown. Here, we conducted a study to describe the global DNA methylation landscape of UTUC and UC...

Full description

Bibliographic Details
Main Authors: Juan Li, Yuan Liang, Jian Fan, Chunru Xu, Bao Guan, Jianye Zhang, Bin Guo, Yue Shi, Ping Wang, Yezhen Tan, Qi Zhang, Changwei Yuan, Yucai Wu, Liqun Zhou, Weimin Ci, Xuesong Li
Format: Article
Language:English
Published: BMC 2022-07-01
Series:BMC Medicine
Subjects:
Upper tract urothelial carcinoma
Urothelial carcinoma of the bladder
Whole-genome bisulfite sequencing
DNA methylation subtype
Prognosis
DNA methyltransferase inhibitor
Online Access:https://doi.org/10.1186/s12916-022-02426-w

Internet

https://doi.org/10.1186/s12916-022-02426-w

Similar Items