Preparation and Characterization of Amino Acids-Based Trimethoprim Salts

Preparation and Characterization of Amino Acids-Based Trimethoprim Salts

Trimethoprim (TMP) is a dihydrofolate reductase (DHFR) inhibitor which prevents the conversion of dihydrofolic acid into tetrahydrofolic acid, resulting in the depletion of the latter and leading to bacterial death. Oral bioavailability of TMP is hindered by both its low solubility and low permeabil...

Full description

Bibliographic Details
Main Authors: Afzal R. Mohammed, Tony Worthington, Peter Hanson, Amr ElShaer, Peter Lambert
Format: Article
Language:English
Published: MDPI AG 2012-02-01
Series:Pharmaceutics
Subjects:
trimethoprim
salt formation
fourier transform infrared
1H nuclear magnetic resonance
thermogrametric analysis
Pseudomonas aeruginosa
minimum inhibitory concentration studies
Online Access:http://www.mdpi.com/1999-4923/4/1/179/

Internet

http://www.mdpi.com/1999-4923/4/1/179/

Similar Items