A foundation for reference models for drug combinations with an application to Loewe’s reference model

A foundation for reference models for drug combinations with an application to Loewe’s reference model

Abstract Background Treating patients with combinations of drugs that have synergistic effects has become widespread practice in the clinic. Drugs work synergistically when the observed effect of a drug combination is larger than the effect predicted by the reference model. The reference model is a...

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Bibliographic Details
Main Authors: Wim De Mulder, Martin Kuiper
Format: Article
Language:English
Published: BMC 2020-10-01
Series:BMC Bioinformatics
Subjects:
Loewe
Complementary dose
Drug combinations
Equivalent dose
Reference model
Online Access:http://link.springer.com/article/10.1186/s12859-020-03771-4

Internet

http://link.springer.com/article/10.1186/s12859-020-03771-4

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