Enhancement of the Anti-Inflammatory Activity of NSAIDs by Their Conjugation with 3,4,5-Trimethoxybenzyl Alcohol

Enhancement of the Anti-Inflammatory Activity of NSAIDs by Their Conjugation with 3,4,5-Trimethoxybenzyl Alcohol

The synthesis of derivatives of three nonspecific COX-1 and COX-2 inhibitors, ibuprofen, ketoprofen, naproxen is presented. These acids were connected via an amide bond with an amino acid (L-proline, L-tyrosine, and beta-alanine) used as a linker. The amino acid carboxylic group was esterified with...

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Bibliographic Details
Main Authors: Paraskevi Tziona, Panagiotis Theodosis-Nobelos, Georgios Papagiouvannis, Anthi Petrou, Chryssoula Drouza, Eleni A. Rekka
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Molecules
Subjects:
non steroidal anti-inflammatory drugs
anti-inflammatory derivatives
cyclooxygenase inhibition
molecular docking
lipoxygenase inhibition
Online Access:https://www.mdpi.com/1420-3049/27/7/2104

Internet

https://www.mdpi.com/1420-3049/27/7/2104

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