Formyl-peptide receptor 2 signalling triggers aerobic metabolism of glucose through Nox2-dependent modulation of pyruvate dehydrogenase activity

Formyl-peptide receptor 2 signalling triggers aerobic metabolism of glucose through Nox2-dependent modulation of pyruvate dehydrogenase activity

The human formyl-peptide receptor 2 (FPR2) is activated by an array of ligands. By phospho-proteomic analysis we proved that FPR2 stimulation induces redox-regulated phosphorylation of many proteins involved in cellular metabolic processes. In this study, we investigated metabolic pathways activated...

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Bibliographic Details
Main Authors: Tiziana Pecchillo Cimmino, Ester Pagano, Mariano Stornaiuolo, Gabriella Esposito, Rosario Ammendola, Fabio Cattaneo
Format: Article
Language:English
Published: The Royal Society 2023-10-01
Series:Open Biology
Subjects:
formyl peptide receptors
NADPH oxidase
reactive oxygen species
tyrosine kinase receptor transactivation
glucose metabolism
Warburg effect
Online Access:https://royalsocietypublishing.org/doi/10.1098/rsob.230336

Internet

https://royalsocietypublishing.org/doi/10.1098/rsob.230336

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