The SREBP-dependent regulation of cyclin D1 coordinates cell proliferation and lipid synthesis

The sterol regulatory-element binding protein (SREBP) family of transcription factors regulates cholesterol, fatty acid, and triglyceride synthesis and metabolism. However, they are also targeted by the ubiquitin ligase Fbw7, a major tumor suppressor, suggesting that they could regulate cell growth....

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Bibliographic Details
Main Authors: Arwa Aldaalis, Maria T. Bengoechea-Alonso, Johan Ericsson
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Oncology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.942386/full