Immunization with cocktail of HIV-derived peptides in montanide ISA-51 is immunogenic, but causes sterile abscesses and unacceptable reactogenicity.

Immunization with cocktail of HIV-derived peptides in montanide ISA-51 is immunogenic, but causes sterile abscesses and unacceptable reactogenicity.

A peptide vaccine was produced containing B and T cell epitopes from the V3 and C4 Envelope domains of 4 subtype B HIV-1 isolates (MN, RF, CanO, & Ev91). The peptide mixture was formulated as an emulsion in incomplete Freund's adjuvant (IFA).Low-risk, healthy adult subjects were enrolled in...

Full description

Bibliographic Details
Main Authors: Barney S Graham, M Juliana McElrath, Michael C Keefer, Kyle Rybczyk, David Berger, Kent J Weinhold, Janet Ottinger, Guido Ferarri, David C Montefiori, Don Stablein, Carol Smith, Richard Ginsberg, John Eldridge, Ann Duerr, Pat Fast, Barton F Haynes, AIDS Vaccine Evaluation Group
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-08-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2919382?pdf=render

Internet

http://europepmc.org/articles/PMC2919382?pdf=render

Similar Items