Whole genome sequence analysis of apparent treatment resistant hypertension status in participants from the Trans-Omics for Precision Medicine program

Whole genome sequence analysis of apparent treatment resistant hypertension status in participants from the Trans-Omics for Precision Medicine program

Introduction: Apparent treatment-resistant hypertension (aTRH) is characterized by the use of four or more antihypertensive (AHT) classes to achieve blood pressure (BP) control. In the current study, we conducted single-variant and gene-based analyses of aTRH among individuals from 12 Trans-Omics fo...

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Main Authors: Nicole D. Armstrong, Vinodh Srinivasasainagendra, Farah Ammous, Themistocles L. Assimes, Amber L. Beitelshees, Jennifer Brody, Brian E. Cade, Yii-Der Ida Chen, Han Chen, Paul S. de Vries, James S. Floyd, Nora Franceschini, Xiuqing Guo, Jacklyn N. Hellwege, John S. House, Chii-Min Hwu, Sharon L. R. Kardia, Ethan M. Lange, Leslie A. Lange, Caitrin W. McDonough, May E. Montasser, Jeffrey R. O’Connell, Megan M. Shuey, Xiao Sun, Rikki M. Tanner, Zhe Wang, Wei Zhao, April P. Carson, Todd L. Edwards, Tanika N. Kelly, Eimear E. Kenny, Charles Kooperberg, Ruth J. F. Loos, Alanna C. Morrison, Alison Motsinger-Reif, Bruce M. Psaty, Dabeeru C. Rao, Susan Redline, Stephen S. Rich, Jerome I. Rotter, Jennifer A. Smith, Albert V. Smith, Marguerite R. Irvin, Donna K. Arnett
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-12-01
Series:Frontiers in Genetics
Subjects:
blood pressure
antihypertensive response
whole genome sequencing
TOPMed
treatment resistant hypertension
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2023.1278215/full

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https://www.frontiersin.org/articles/10.3389/fgene.2023.1278215/full

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