Short tandem repeat polymorphism in the promoter region of cyclophilin 19B drives its transcriptional upregulation and contributes to drug resistance in the malaria parasite Plasmodium falciparum.

Short tandem repeat polymorphism in the promoter region of cyclophilin 19B drives its transcriptional upregulation and contributes to drug resistance in the malaria parasite Plasmodium falciparum.

Resistance of the human malaria parasites, Plasmodium falciparum, to artemisinins is now fully established in Southeast Asia and is gradually emerging in Sub-Saharan Africa. Although nonsynonymous SNPs in the pfk13 Kelch-repeat propeller (KREP) domain are clearly associated with artemisinin resistan...

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Bibliographic Details
Main Authors: Michal Kucharski, Grennady Wirjanata, Sourav Nayak, Josephine Boentoro, Jerzy Michal Dziekan, Christina Assisi, Rob W van der Pluijm, Olivo Miotto, Sachel Mok, Arjen M Dondorp, Zbynek Bozdech
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-01-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1011118

Internet

https://doi.org/10.1371/journal.ppat.1011118

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