Common pitfalls in drug target Mendelian randomization and how to avoid them

Common pitfalls in drug target Mendelian randomization and how to avoid them

Abstract Background Drug target Mendelian randomization describes the use of genetic variants as instrumental variables for studying the effects of pharmacological agents. The paradigm can be used to inform on all aspects of drug development and has become increasingly popular over the last decade,...

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Bibliographic Details
Main Authors: Dipender Gill, Marie-Joe Dib, Héléne T. Cronjé, Ville Karhunen, Benjamin Woolf, Eloi Gagnon, Iyas Daghlas, Michael Nyberg, Donald Drakeman, Stephen Burgess
Format: Article
Language:English
Published: BMC 2024-10-01
Series:BMC Medicine
Subjects:
Mendelian randomization
Drug target
Pharmacology
Drug development
Online Access:https://doi.org/10.1186/s12916-024-03700-9

Internet

https://doi.org/10.1186/s12916-024-03700-9

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