Inhibition of the Aquaporin-1 Cation Conductance by Selected Furan Compounds Reduces Red Blood Cell Sickling

Inhibition of the Aquaporin-1 Cation Conductance by Selected Furan Compounds Reduces Red Blood Cell Sickling

In sickle cell disease (SCD), the pathological shift of red blood cells (RBCs) into distorted morphologies under hypoxic conditions follows activation of a cationic leak current (Psickle) and cell dehydration. Prior work showed sickling was reduced by 5-hydroxylmethyl-2-furfural (5-HMF), which stabi...

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Bibliographic Details
Main Authors: Pak Hin Chow, Charles D. Cox, Jinxin V. Pei, Nancy Anabaraonye, Saeed Nourmohammadi, Sam W. Henderson, Boris Martinac, Osheiza Abdulmalik, Andrea J. Yool
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Pharmacology
Subjects:
AQP1
cyclic GMP
Piezo1 channel
psickle
erythrocyte
RBC
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.794791/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.794791/full

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