GSK3β is a critical, druggable component of the network regulating the active NOTCH1 protein and cell viability in CLL

GSK3β is a critical, druggable component of the network regulating the active NOTCH1 protein and cell viability in CLL

Abstract NOTCH1 alterations have been associated with chronic lymphocytic leukemia (CLL), but the molecular mechanisms underlying NOTCH1 activation in CLL cells are not completely understood. Here, we show that GSK3β downregulates the constitutive levels of the active NOTCH1 intracellular domain (N1...

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Bibliographic Details
Main Authors: Filomena De Falco, Chiara Rompietti, Daniele Sorcini, Angela Esposito, Annarita Scialdone, Stefano Baldoni, Beatrice Del Papa, Francesco Maria Adamo, Estevão Carlos Silva Barcelos, Erica Dorillo, Arianna Stella, Mauro Di Ianni, Isabella Screpanti, Paolo Sportoletti, Emanuela Rosati
Format: Article
Language:English
Published: Nature Publishing Group 2022-09-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-022-05178-w

Internet

https://doi.org/10.1038/s41419-022-05178-w

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