Downregulation of oxidative stress-mediated glial innate immune response suppresses seizures in a fly epilepsy model

Downregulation of oxidative stress-mediated glial innate immune response suppresses seizures in a fly epilepsy model

Summary: Previous work in our laboratory has shown that mutations in prickle (pk) cause myoclonic-like seizures and ataxia in Drosophila, similar to what is observed in humans carrying mutations in orthologous PRICKLE genes. Here, we show that pk mutant brains show elevated, sustained neuronal cell...

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Bibliographic Details
Main Authors: Krishna M. Nukala, Anthony J. Lilienthal, Shu Hui Lye, Alexander G. Bassuk, Stanislava Chtarbanova, J. Robert Manak
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Cell Reports
Subjects:
CP: Neuroscience
CP: Immunology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723000153

Internet

http://www.sciencedirect.com/science/article/pii/S2211124723000153

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