Attenuating ribosome load improves protein output from mRNA by limiting translation-dependent mRNA decay

Attenuating ribosome load improves protein output from mRNA by limiting translation-dependent mRNA decay

Summary: Developing an effective mRNA therapeutic often requires maximizing protein output per delivered mRNA molecule. We previously found that coding sequence (CDS) design can substantially affect protein output, with mRNA variants containing more optimal codons and higher secondary structure yiel...

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Bibliographic Details
Main Authors: Alicia A. Bicknell, David W. Reid, Marissa C. Licata, Adriana K. Jones, Yi Min Cheng, Mengying Li, Chiaowen Joyce Hsiao, Christopher S. Pepin, Mihir Metkar, Yevgen Levdansky, Brian R. Fritz, Elizaveta A. Andrianova, Ruchi Jain, Eugene Valkov, Caroline Köhrer, Melissa J. Moore
Format: Article
Language:English
Published: Elsevier 2024-04-01
Series:Cell Reports
Subjects:
CP: Molecular biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124724004261

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http://www.sciencedirect.com/science/article/pii/S2211124724004261

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