CYP1A1 m1 and m2 polymorphisms: genetic susceptibility to lung cancer Polimorfismos dos alelos m1 e m2 do gene CYP1A1: Susceptibilidade genética para o cancro do pulmão

CYP1A1 m1 and m2 polymorphisms: genetic susceptibility to lung cancer Polimorfismos dos alelos m1 e m2 do gene CYP1A1: Susceptibilidade genética para o cancro do pulmão

Lung cancer is considered an environment-related disease that develops as a consequence of exposure to mutagenic agents, namely those present in tobacco. The CYP1A1 gene codifies the phase I enzyme aryl hydrocarbon hydroxilase (AHH) belonging to the cytochrome P450 system that plays a major role in...

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Bibliographic Details
Main Authors: Paula Mota, David Silva Moura, Maria Graça Vale, Henriqueta Coimbra, Lina Carvalho, Fernando Regateiro
Format: Article
Language:English
Published: Elsevier 2010-01-01
Series:Revista Portuguesa de Pneumologia
Subjects:
Cancro do pulmão
tabaco
citocromo p450
CYP1A1
desequilíbrio de ligação
Lung cancer
smoking
cytochrome P450
linkage disequilibrium
Online Access:http://www.scielo.oces.mctes.pt/scielo.php?script=sci_arttext&pid=S0873-21592010000100005

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