Development of thermosensitive hydrogel of Amphotericin-B and Lactoferrin combination-loaded PLGA-PEG-PEI nanoparticles for potential eradication of ocular fungal infections: In-vitro, ex-vivo and in-vivo studies

Development of thermosensitive hydrogel of Amphotericin-B and Lactoferrin combination-loaded PLGA-PEG-PEI nanoparticles for potential eradication of ocular fungal infections: In-vitro, ex-vivo and in-vivo studies

The most prevalent conditions among ocular surgery and COVID−19 patients are fungal eye infections, which may cause inflammation and dry eye, and may cause ocular morbidity. Amphotericin-B eye drops are commonly used in the treatment of ocular fungal infections. Lactoferrin is an iron-binding glycop...

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Bibliographic Details
Main Authors: Sammar Fathy Elhabal, Shrouk A. Ghaffar, Raghda Hager, Nahla A. Elzohairy, Mohamed Mansour Khalifa, Passant M. Mohie, Rania A. Gad, Nasreen N. Omar, Mohammed H. Elkomy, Mohammad Ahmad Khasawneh, Nashwa Abdelaal
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:International Journal of Pharmaceutics: X
Subjects:
Amphotericin-B
Lactoferrin
Candida albicans
Confocal laser scanning microscopy (CLSM)
Draize test
Nanoparticles
Online Access:http://www.sciencedirect.com/science/article/pii/S259015672300018X

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http://www.sciencedirect.com/science/article/pii/S259015672300018X

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