Lipid Nanoparticles Delivering Constitutively Active STING mRNA to Stimulate Antitumor Immunity

Lipid Nanoparticles Delivering Constitutively Active STING mRNA to Stimulate Antitumor Immunity

Treating immunosuppressive tumors represents a major challenge in cancer therapies. Activation of STING signaling has shown remarkable potential to invigorate the immunologically “cold” tumor microenvironment (TME). However, we have shown that STING is silenced in many human cancers, including pancr...

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Bibliographic Details
Main Authors: Wei Liu, Mohamad-Gabriel Alameh, June F. Yang, Jonathan R. Xu, Paulo J. C. Lin, Ying K. Tam, Drew Weissman, Jianxin You
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:International Journal of Molecular Sciences
Subjects:
lipid nanoparticles
constitutively active STING
mRNA
therapeutic approach
cancer
Online Access:https://www.mdpi.com/1422-0067/23/23/14504

Internet

https://www.mdpi.com/1422-0067/23/23/14504

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