Structural basis of the activation of TRPV5 channels by long-chain acyl-Coenzyme-A

Abstract Long-chain acyl-coenzyme A (LC-CoA) is a crucial metabolic intermediate that plays important cellular regulatory roles, including activation and inhibition of ion channels. The structural basis of ion channel regulation by LC-CoA is not known. Transient receptor potential vanilloid 5 and 6...

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Bibliographic Details
Main Authors: Bo-Hyun Lee, José J. De Jesús Pérez, Vera Moiseenkova-Bell, Tibor Rohacs
Format: Article
Language:English
Published: Nature Portfolio 2023-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-41577-z