Novel Metabolomic Approach for Identifying Pathology-Specific Biomarkers in Rare Diseases: A Case Study in Oculopharyngeal Muscular Dystrophy (OPMD)

Novel Metabolomic Approach for Identifying Pathology-Specific Biomarkers in Rare Diseases: A Case Study in Oculopharyngeal Muscular Dystrophy (OPMD)

The identification of metabolomic biomarkers relies on the analysis of large cohorts of patients compared to healthy controls followed by the validation of markers in an independent sample set. Indeed, circulating biomarkers should be causally linked to pathology to ensure that changes in the marker...

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Bibliographic Details
Main Authors: Pradeep Harish, Alberto Malerba, Rosemarie H. M. J. M. Kroon, Milad Shademan, Baziel van Engelan, Vered Raz, Linda Popplewell, Stuart G. Snowden
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Metabolites
Subjects:
biomarker
metabolomics
LC-MS
random forest
oculopharyngeal muscular dystrophy
Online Access:https://www.mdpi.com/2218-1989/13/6/769

Internet

https://www.mdpi.com/2218-1989/13/6/769

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