Multimodal CRISPR perturbations of GWAS loci associated with coronary artery disease in vascular endothelial cells.

Multimodal CRISPR perturbations of GWAS loci associated with coronary artery disease in vascular endothelial cells.

Genome-wide association studies have identified >250 genetic variants associated with coronary artery disease (CAD), but the causal variants, genes and molecular mechanisms remain unknown at most loci. We performed pooled CRISPR screens to test the impact of sequences at or near CAD-associated ge...

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Bibliographic Details
Main Authors: Florian Wünnemann, Thierry Fotsing Tadjo, Mélissa Beaudoin, Simon Lalonde, Ken Sin Lo, Benjamin P Kleinstiver, Guillaume Lettre
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-03-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1010680

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https://doi.org/10.1371/journal.pgen.1010680

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