Dapagliflozin Ameliorates Cognitive Impairment in Aluminum-Chloride-Induced Alzheimer’s Disease via Modulation of AMPK/mTOR, Oxidative Stress and Glucose Metabolism

Dapagliflozin Ameliorates Cognitive Impairment in Aluminum-Chloride-Induced Alzheimer’s Disease via Modulation of AMPK/mTOR, Oxidative Stress and Glucose Metabolism

Alzheimer’s disease (AD) is a progressive neurological illness characterized by memory loss and cognitive deterioration. Dapagliflozin was suggested to attenuate the memory impairment associated with AD; however, its mechanisms were not fully elucidated. This study aims to examine the possible mecha...

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Bibliographic Details
Main Authors: Waad A. Samman, Salma M. Selim, Hassan M. El Fayoumi, Norhan M. El-Sayed, Eman T. Mehanna, Reem M. Hazem
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Pharmaceuticals
Subjects:
Alzheimer’s disease
dapagliflozin
AMPK pathway
oxidative stress
glucose metabolism
Online Access:https://www.mdpi.com/1424-8247/16/5/753

Internet

https://www.mdpi.com/1424-8247/16/5/753

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