High-Mobility Group Box 1 Inhibitor BoxA Alleviates Neuroinflammation-Induced Retinal Ganglion Cell Damage in Traumatic Optic Neuropathy

High-Mobility Group Box 1 Inhibitor BoxA Alleviates Neuroinflammation-Induced Retinal Ganglion Cell Damage in Traumatic Optic Neuropathy

Traumatic optic neuropathy (TON) is a significant cause of vision loss and irreversible blindness worldwide. It is defined as retinal ganglion cell death and axon degeneration caused by injury. Optic nerve crush (ONC), a well-validated model of TON, activates retinal microglia and initiates neuroinf...

Full description

Bibliographic Details
Main Authors: Jingyi Peng, Jiayi Jin, Wenru Su, Wanwen Shao, Weihua Li, Zhiquan Li, Huan Yu, Yongxin Zheng, Liuxueying Zhong
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:International Journal of Molecular Sciences
Subjects:
TON
ONC
neuroinflammation
RGCs
HMGB1
BoxA
Online Access:https://www.mdpi.com/1422-0067/23/12/6715

Internet

https://www.mdpi.com/1422-0067/23/12/6715

Similar Items