Comprehensive assessment of NR ligand polypharmacology by a multiplex reporter NR assay

Comprehensive assessment of NR ligand polypharmacology by a multiplex reporter NR assay

Abstract Nuclear receptors (NR) are ligand-modulated transcription factors that regulate multiple cell functions and thus represent excellent drug targets. However, due to a considerable NR structural homology, NR ligands often interact with multiple receptors. Here, we describe a multiplex reporter...

Full description

Bibliographic Details
Main Authors: Alexander Medvedev, Matt Moeser, Liubov Medvedeva, Elena Martsen, Alexander Granick, Lydia Raines, Kristen Gorman, Benjamin Lin, Ming Zeng, Keith A. Houck, Sergei S. Makarov
Format: Article
Language:English
Published: Nature Portfolio 2022-02-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-07031-8

Internet

https://doi.org/10.1038/s41598-022-07031-8

Similar Items