TLR7 Activation Accelerates Cardiovascular Pathology in a Mouse Model of Lupus

TLR7 Activation Accelerates Cardiovascular Pathology in a Mouse Model of Lupus

We report a novel model of lupus-associated cardiovascular pathology accelerated by the TLR7 agonist R848 in lupus-prone B6.Sle1.Sle2.Sle3 (TC) mice. R848-treated TC mice but not non-autoimmune C57BL/6 (B6) controls developed microvascular inflammation and myocytolysis with intracellular vacuolizati...

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Bibliographic Details
Main Authors: Ahmed S. Elshikha, Xiang Yu Teng, Nathalie Kanda, Wei Li, Seung-Chul Choi, Georges Abboud, Morgan Terrell, Kristianna Fredenburg, Laurence Morel
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Immunology
Subjects:
lupus
cardiovascular disease
TLR7
mouse models
autoimmunity
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.914468/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.914468/full

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