Functional implication of ubiquitinating and deubiquitinating mechanisms in TDP-43 proteinopathies

Functional implication of ubiquitinating and deubiquitinating mechanisms in TDP-43 proteinopathies

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease in which motor neurons in spinal cord and motor cortex are progressively lost. About 15% cases of ALS also develop the frontotemporal dementia (FTD), in which the frontotemporal lobar degeneration (FTLD) occurs in the frontal a...

Full description

Bibliographic Details
Main Authors: Non-Nuoc Tran, Byung-Hoon Lee
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
ubiquitinating enzyme
deubiquitinating enzyme
ubiquitin-proteasome system
TDP-43
protein quality control
proteinopathy
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2022.931968/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2022.931968/full

Similar Items