The bacterial defensin resistance protein MprF consists of separable domains for lipid lysinylation and antimicrobial peptide repulsion.

The bacterial defensin resistance protein MprF consists of separable domains for lipid lysinylation and antimicrobial peptide repulsion.

Many bacterial pathogens achieve resistance to defensin-like cationic antimicrobial peptides (CAMPs) by the multiple peptide resistance factor (MprF) protein. MprF plays a crucial role in Staphylococcus aureus virulence and it is involved in resistance to the CAMP-like antibiotic daptomycin. MprF is...

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Bibliographic Details
Main Authors: Christoph M Ernst, Petra Staubitz, Nagendra N Mishra, Soo-Jin Yang, Gabriele Hornig, Hubert Kalbacher, Arnold S Bayer, Dirk Kraus, Andreas Peschel
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-11-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC2774229?pdf=render

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http://europepmc.org/articles/PMC2774229?pdf=render

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