Rational design of the genetic code expansion toolkit for in vivo encoding of D-amino acids

Rational design of the genetic code expansion toolkit for in vivo encoding of D-amino acids

Once thought to be non-naturally occurring, D-amino acids (DAAs) have in recent years been revealed to play a wide range of physiological roles across the tree of life, including in human systems. Synthetic biologists have since exploited DAAs’ unique biophysical properties to generate peptides and...

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Bibliographic Details
Main Authors: Han-Kai Jiang, Jui-Hung Weng, Yi-Hui Wang, Jo-Chu Tsou, Pei-Jung Chen, An-Li Andrea Ko, Dieter Söll, Ming-Daw Tsai, Yane-Shih Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-10-01
Series:Frontiers in Genetics
Subjects:
pyrrolysyl-tRNA synthetase
genetic code expansion
noncanonical amino acids
D-phenylalanine analogs
synthetic biology
amber suppression
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2023.1277489/full

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https://www.frontiersin.org/articles/10.3389/fgene.2023.1277489/full

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