Expression and Function of StAR in Cancerous and Non-Cancerous Human and Mouse Breast Tissues: New Insights into Diagnosis and Treatment of Hormone-Sensitive Breast Cancer

Expression and Function of StAR in Cancerous and Non-Cancerous Human and Mouse Breast Tissues: New Insights into Diagnosis and Treatment of Hormone-Sensitive Breast Cancer

Breast cancer (BC) is primarily triggered by estrogens, especially 17β-estradiol (E2), which are synthesized by the aromatase enzyme. While all steroid hormones are derived from cholesterol, the rate-limiting step in steroid biosynthesis is mediated by the steroidogenic acute regulatory (StAR) prote...

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Bibliographic Details
Main Authors: Pulak R. Manna, Sabarish Ramachandran, Jangampalli Adi Pradeepkiran, Deborah Molehin, Isabel Castro-Piedras, Kevin Pruitt, Vadivel Ganapathy, P. Hemachandra Reddy
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:International Journal of Molecular Sciences
Subjects:
breast cancer
StAR
aromatase
estrogen/E2
hormone-sensitive BC
mouse models of BCs
Online Access:https://www.mdpi.com/1422-0067/24/1/758

Internet

https://www.mdpi.com/1422-0067/24/1/758

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