R-Loops and R-Loop-Binding Proteins in Cancer Progression and Drug Resistance

R-Loops and R-Loop-Binding Proteins in Cancer Progression and Drug Resistance

R-loops are three-stranded DNA/RNA hybrids that form by the annealing of the mRNA transcript to its coding template while displacing the non-coding strand. While R-loop formation regulates physiological genomic and mitochondrial transcription and DNA damage response, imbalanced R-loop formation can...

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Bibliographic Details
Main Authors: Noha Elsakrmy, Haissi Cui
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:International Journal of Molecular Sciences
Subjects:
R-loops
RNA-DNA hybrids
cancer
chemotherapy
drug resistance
ATR
Online Access:https://www.mdpi.com/1422-0067/24/8/7064

Internet

https://www.mdpi.com/1422-0067/24/8/7064

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