Diminazene Aceturate Reduces Angiotensin II Constriction and Interacts with the Spike Protein of Severe Acute Respiratory Syndrome Coronavirus 2

Diminazene Aceturate Reduces Angiotensin II Constriction and Interacts with the Spike Protein of Severe Acute Respiratory Syndrome Coronavirus 2

Diminazene aceturate (DIZE) is a putative angiotensin-converting enzyme 2 (ACE2) activator and angiotensin type 1 receptor antagonist (AT<sub>1</sub>R). Its simple chemical structure possesses a negatively charged triazene segment that is homologous to the tetrazole of angiotensin recept...

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Bibliographic Details
Main Authors: John M. Matsoukas, Laura Kate Gadanec, Anthony Zulli, Vasso Apostolopoulos, Konstantinos Kelaidonis, Irene Ligielli, Kalliopi Moschovou, Nikitas Georgiou, Panagiotis Plotas, Christos T. Chasapis, Graham Moore, Harry Ridgway, Thomas Mavromoustakos
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Biomedicines
Subjects:
angiotensin-converting enzyme 2
angiotensin II
angiotensin type 1 receptor
coronavirus 2019
diminazene aceturate
sartans
Online Access:https://www.mdpi.com/2227-9059/10/7/1731

Internet

https://www.mdpi.com/2227-9059/10/7/1731

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