A novel “prime and pull” strategy mediated by the combination of two dendritic cell-targeting designs induced protective lung tissue-resident memory T cells against H1N1 influenza virus challenge

A novel “prime and pull” strategy mediated by the combination of two dendritic cell-targeting designs induced protective lung tissue-resident memory T cells against H1N1 influenza virus challenge

Abstract Vaccination is still the most promising strategy for combating influenza virus pandemics. However, the highly variable characteristics of influenza virus make it difficult to develop antibody-based universal vaccines, until now. Lung tissue-resident memory T cells (TRM), which actively surv...

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Bibliographic Details
Main Authors: Zhannan Wang, Yingkai He, Wenfeng Wang, Yawen Tian, Chongbo Ge, Futing Jia, Tongyu Zhang, Gerui Zhang, Mingyue Wang, Jinshuo Gong, Haibin Huang, Jianzhong Wang, Chunwei Shi, Wentao Yang, Xin Cao, Yan Zeng, Nan Wang, Aidong Qian, Yanlong Jiang, Guilian Yang, Chunfeng Wang
Format: Article
Language:English
Published: BMC 2023-12-01
Series:Journal of Nanobiotechnology
Subjects:
Influenza virus
Nanoparticle vaccine
DC targeting
Sequential immunization
TRM cell
Online Access:https://doi.org/10.1186/s12951-023-02229-y

Internet

https://doi.org/10.1186/s12951-023-02229-y

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