Identification of membrane curvature sensing motifs essential for VPS37A phagophore recruitment and autophagosome closure

Identification of membrane curvature sensing motifs essential for VPS37A phagophore recruitment and autophagosome closure

Abstract VPS37A, an ESCRT-I complex component, is required for recruiting a subset of ESCRT proteins to the phagophore for autophagosome closure. However, the mechanism by which VPS37A is targeted to the phagophore remains obscure. Here, we demonstrate that the VPS37A N-terminal domain exhibits sele...

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Bibliographic Details
Main Authors: Yansheng Ye, Xinwen Liang, Guifang Wang, Maria C. Bewley, Kouta Hamamoto, Xiaoming Liu, John M. Flanagan, Hong-Gang Wang, Yoshinori Takahashi, Fang Tian
Format: Article
Language:English
Published: Nature Portfolio 2024-03-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-024-06026-7

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https://doi.org/10.1038/s42003-024-06026-7

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