Mfn2 Regulates High Glucose-Induced MAMs Dysfunction and Apoptosis in Podocytes via PERK Pathway

Mfn2 Regulates High Glucose-Induced MAMs Dysfunction and Apoptosis in Podocytes via PERK Pathway

The endoplasmic reticulum (ER) stress and mitochondrial dysfunction in high glucose (HG)-induced podocyte injury have been demonstrated to the progression of diabetic kidney disease (DKD). However, the pathological mechanisms remain equivocal. Mitofusin2 (Mfn2) was initially identified as a dynamin-...

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Bibliographic Details
Main Authors: Yun Cao, Zhaowei Chen, Jijia Hu, Jun Feng, Zijing Zhu, Yanqin Fan, Qiaoxuan Lin, Guohua Ding
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-12-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
DKD
podocyte
Mfn2
MAMs
ER stress
apoptosis
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.769213/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.769213/full

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