Inducible deletion of skeletal muscle AMPKα reveals that AMPK is required for nucleotide balance but dispensable for muscle glucose uptake and fat oxidation during exercise

Inducible deletion of skeletal muscle AMPKα reveals that AMPK is required for nucleotide balance but dispensable for muscle glucose uptake and fat oxidation during exercise

Objective: Evidence for AMP-activated protein kinase (AMPK)-mediated regulation of skeletal muscle metabolism during exercise is mainly based on transgenic mouse models with chronic (lifelong) disruption of AMPK function. Findings based on such models are potentially biased by secondary effects rela...

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Bibliographic Details
Main Authors: Janne R. Hingst, Rasmus Kjøbsted, Jesper B. Birk, Nicolas O. Jørgensen, Magnus R. Larsen, Kohei Kido, Jeppe Kjærgaard Larsen, Sasha A.S. Kjeldsen, Joachim Fentz, Christian Frøsig, Stephanie Holm, Andreas M. Fritzen, Tine L. Dohlmann, Steen Larsen, Marc Foretz, Benoit Viollet, Peter Schjerling, Peter Overby, Jens F. Halling, Henriette Pilegaard, Ylva Hellsten, Jørgen F.P. Wojtaszewski
Format: Article
Language:English
Published: Elsevier 2020-10-01
Series:Molecular Metabolism
Subjects:
AMPK
Exercise
Glucose uptake
Muscle metabolism
Fat oxidation
Glycogen
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877820301022

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http://www.sciencedirect.com/science/article/pii/S2212877820301022

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