The genetic and mechanistic basis for variation in gene regulation.

It is now well established that noncoding regulatory variants play a central role in the genetics of common diseases and in evolution. However, until recently, we have known little about the mechanisms by which most regulatory variants act. For instance, what types of functional elements in DNA, RNA...

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Bibliographic Details
Main Authors: Athma A Pai, Jonathan K Pritchard, Yoav Gilad
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC4287341?pdf=render