The Impact of Meat Intake on Bladder Cancer Incidence: Is It Really a Relevant Risk?
Bladder cancer (BC) represents the second most common genitourinary malignancy. The major risk factors for BC include age, gender, smoking, occupational exposure, and infections. The BC etiology and pathogenesis have not been fully defined yet. Since catabolites are excreted through the urinary trac...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-09-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/14/19/4775 |
| _version_ | 1797480210196594688 |
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| author | Achille Aveta Crescenzo Cacciapuoti Biagio Barone Erika Di Zazzo Francesco Del Giudice Martina Maggi Matteo Ferro Daniela Terracciano Gian Maria Busetto Giuseppe Lucarelli Octavian Sabin Tataru Emanuele Montanari Benito Fabio Mirto Alfonso Falcone Gaetano Giampaglia Enrico Sicignano Federico Capone Gianluca Villano Pasquale Angellotto Celeste Manfredi Luigi Napolitano Ciro Imbimbo Savio Domenico Pandolfo Felice Crocetto |
| author_facet | Achille Aveta Crescenzo Cacciapuoti Biagio Barone Erika Di Zazzo Francesco Del Giudice Martina Maggi Matteo Ferro Daniela Terracciano Gian Maria Busetto Giuseppe Lucarelli Octavian Sabin Tataru Emanuele Montanari Benito Fabio Mirto Alfonso Falcone Gaetano Giampaglia Enrico Sicignano Federico Capone Gianluca Villano Pasquale Angellotto Celeste Manfredi Luigi Napolitano Ciro Imbimbo Savio Domenico Pandolfo Felice Crocetto |
| author_sort | Achille Aveta |
| collection | DOAJ |
| description | Bladder cancer (BC) represents the second most common genitourinary malignancy. The major risk factors for BC include age, gender, smoking, occupational exposure, and infections. The BC etiology and pathogenesis have not been fully defined yet. Since catabolites are excreted through the urinary tract, the diet may play a pivotal role in bladder carcinogenesis. Meat, conventionally classified as “red”, “white” or “processed”, represents a significant risk factor for chronic diseases like cardiovascular disease, obesity, type 2 diabetes, and cancer. In particular, red and processed meat consumption seems to increase the risk of BC onset. The most accepted mechanism proposed for explaining the correlation between meat intake and BC involves the generation of carcinogens, such as heterocyclic amines and polycyclic aromatic hydrocarbons by high-temperature cooking. This evidence claims the consumption limitation of meat. We reviewed the current literature on potential biological mechanisms underlying the impact of meat (red, white, and processed) intake on the increased risk of BC development and progression. Toward this purpose, we performed an online search on PubMed using the term “bladder cancer” in combination with “meat”, “red meat”, “white meat” or “processed meat”. Although some studies did not report any association between BC and meat intake, several reports highlighted a positive correlation between red or processed meat intake, especially salami, pastrami, corned beef and bacon, and BC risk. We speculate that a reduction or rather a weighting of the consumption of red and processed meat can reduce the risk of developing BC. Obviously, this remark claims future indications regarding food education (type of meat to be preferred, quantity of red meat to be eaten and how to cook it) to reduce the risk of developing BC. Further well-designed prospective studies are needed to corroborate these findings. |
| first_indexed | 2024-03-09T21:56:49Z |
| format | Article |
| id | doaj.art-7b65b032a53a488696e9cb5372ef5286 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T21:56:49Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-7b65b032a53a488696e9cb5372ef52862023-11-23T19:56:25ZengMDPI AGCancers2072-66942022-09-011419477510.3390/cancers14194775The Impact of Meat Intake on Bladder Cancer Incidence: Is It Really a Relevant Risk?Achille Aveta0Crescenzo Cacciapuoti1Biagio Barone2Erika Di Zazzo3Francesco Del Giudice4Martina Maggi5Matteo Ferro6Daniela Terracciano7Gian Maria Busetto8Giuseppe Lucarelli9Octavian Sabin Tataru10Emanuele Montanari11Benito Fabio Mirto12Alfonso Falcone13Gaetano Giampaglia14Enrico Sicignano15Federico Capone16Gianluca Villano17Pasquale Angellotto18Celeste Manfredi19Luigi Napolitano20Ciro Imbimbo21Savio Domenico Pandolfo22Felice Crocetto23Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II, 80131 Naples, ItalyDepartment of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II, 80131 Naples, ItalyDepartment of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II, 80131 Naples, ItalyDepartment of Precision Medicine, University of Campania “Luigi Vanvitelli”, 80138 Naples, ItalyDepartment of Maternal Infant and Urologic Sciences, Policlinico Umberto I Hospital, “Sapienza” University of Rome, 00161 Rome, ItalyDepartment of Maternal Infant and Urologic Sciences, Policlinico Umberto I Hospital, “Sapienza” University of Rome, 00161 Rome, ItalyDivision of Urology, European Institute of Oncology IRCCS, 20141 Milan, ItalyDepartment of Translational Medical Sciences, University of Naples “Federico II”, 80131 Naples, ItalyDepartment of Urology and Organ Transplantation, University of Foggia, 71122 Foggia, ItalyUrology, Andrology and Kidney Transplantation Unit, Department of Emergency and Organ Transplantation, University of Bari, 70124 Bari, ItalyThe Institution Organizing University Doctoral Studies (I.O.S.U.D.), George Emil Palade University of Medicine, Pharmacy, Sciences and Technology, 540142 Târgu Mureș, RomaniaDepartment of Urology, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Via della Commenda 15, 20122 Milan, ItalyDepartment of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II, 80131 Naples, ItalyDepartment of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II, 80131 Naples, ItalyDepartment of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II, 80131 Naples, ItalyDepartment of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II, 80131 Naples, ItalyDepartment of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II, 80131 Naples, ItalyDepartment of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II, 80131 Naples, ItalyDepartment of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II, 80131 Naples, ItalyUrology Unit, Department of Woman Child and of General and Specialist Surgery, University of Campania “Luigi Vanvitelli”, 80121 Naples, ItalyDepartment of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II, 80131 Naples, ItalyDepartment of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II, 80131 Naples, ItalyDepartment of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II, 80131 Naples, ItalyDepartment of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II, 80131 Naples, ItalyBladder cancer (BC) represents the second most common genitourinary malignancy. The major risk factors for BC include age, gender, smoking, occupational exposure, and infections. The BC etiology and pathogenesis have not been fully defined yet. Since catabolites are excreted through the urinary tract, the diet may play a pivotal role in bladder carcinogenesis. Meat, conventionally classified as “red”, “white” or “processed”, represents a significant risk factor for chronic diseases like cardiovascular disease, obesity, type 2 diabetes, and cancer. In particular, red and processed meat consumption seems to increase the risk of BC onset. The most accepted mechanism proposed for explaining the correlation between meat intake and BC involves the generation of carcinogens, such as heterocyclic amines and polycyclic aromatic hydrocarbons by high-temperature cooking. This evidence claims the consumption limitation of meat. We reviewed the current literature on potential biological mechanisms underlying the impact of meat (red, white, and processed) intake on the increased risk of BC development and progression. Toward this purpose, we performed an online search on PubMed using the term “bladder cancer” in combination with “meat”, “red meat”, “white meat” or “processed meat”. Although some studies did not report any association between BC and meat intake, several reports highlighted a positive correlation between red or processed meat intake, especially salami, pastrami, corned beef and bacon, and BC risk. We speculate that a reduction or rather a weighting of the consumption of red and processed meat can reduce the risk of developing BC. Obviously, this remark claims future indications regarding food education (type of meat to be preferred, quantity of red meat to be eaten and how to cook it) to reduce the risk of developing BC. Further well-designed prospective studies are needed to corroborate these findings.https://www.mdpi.com/2072-6694/14/19/4775bladder cancerred meatprocessed meatwhite meatpreventiondiet |
| spellingShingle | Achille Aveta Crescenzo Cacciapuoti Biagio Barone Erika Di Zazzo Francesco Del Giudice Martina Maggi Matteo Ferro Daniela Terracciano Gian Maria Busetto Giuseppe Lucarelli Octavian Sabin Tataru Emanuele Montanari Benito Fabio Mirto Alfonso Falcone Gaetano Giampaglia Enrico Sicignano Federico Capone Gianluca Villano Pasquale Angellotto Celeste Manfredi Luigi Napolitano Ciro Imbimbo Savio Domenico Pandolfo Felice Crocetto The Impact of Meat Intake on Bladder Cancer Incidence: Is It Really a Relevant Risk? Cancers bladder cancer red meat processed meat white meat prevention diet |
| title | The Impact of Meat Intake on Bladder Cancer Incidence: Is It Really a Relevant Risk? |
| title_full | The Impact of Meat Intake on Bladder Cancer Incidence: Is It Really a Relevant Risk? |
| title_fullStr | The Impact of Meat Intake on Bladder Cancer Incidence: Is It Really a Relevant Risk? |
| title_full_unstemmed | The Impact of Meat Intake on Bladder Cancer Incidence: Is It Really a Relevant Risk? |
| title_short | The Impact of Meat Intake on Bladder Cancer Incidence: Is It Really a Relevant Risk? |
| title_sort | impact of meat intake on bladder cancer incidence is it really a relevant risk |
| topic | bladder cancer red meat processed meat white meat prevention diet |
| url | https://www.mdpi.com/2072-6694/14/19/4775 |
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