The role of 9-O-acetylated glycan receptor moieties in the typhoid toxin binding and intoxication.

Typhoid toxin is an A2B5 toxin secreted from Salmonella Typhi-infected cells during human infection and is suggested to contribute to typhoid disease progression and the establishment of chronic infection. To deliver the enzymatic 'A' subunits of the toxin to the site of action in host cel...

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Bibliographic Details
Main Authors: Tri Nguyen, Sohyoung Lee, Yi-An Yang, Changhwan Ahn, Ji Hyun Sim, Tiffany G Kei, Karen N Barnard, Hai Yu, Shawn K Millano, Xi Chen, Colin R Parrish, Jeongmin Song
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-02-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1008336