Lactacystin-induced kidney fibrosis: Protection by melatonin and captopril

Lactacystin-induced kidney fibrosis: Protection by melatonin and captopril

Lactacystin is a specific proteasome inhibitor that blocks the hydrolysis of intracellular proteins by ubiquitin/proteasome system inhibition. The administration of lactacystin to rats induced hypertension and remodeling of the left ventricle and aorta. This study tested whether lactacystin induces...

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Bibliographic Details
Main Authors: Kristina Repova, Peter Stanko, Tomas Baka, Kristina Krajcirovicova, Silvia Aziriova, Jaroslav Hrenak, Andrej Barta, Stefan Zorad, Russel J. Reiter, Michaela Adamcova, Fedor Simko
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Pharmacology
Subjects:
lactacystin
melatonin
captopril
kidney injury
fibrotic remodeling
cardiorenal damage
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.978337/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.978337/full

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