Trichosanthin alleviates streptozotocin-induced type 1 diabetes mellitus in mice by regulating the balance between bone marrow-derived IL6+ and IL10+ MDSCs

Trichosanthin alleviates streptozotocin-induced type 1 diabetes mellitus in mice by regulating the balance between bone marrow-derived IL6+ and IL10+ MDSCs

Myeloid-derived suppressor cells (MDSCs) occupy a pivotal role in the intricate pathogenesis of the autoimmune disorder, Type 1 diabetes mellitus (T1DM). Since our previous work demonstrated that trichosanthin (TCS), an active compound of Chinese herb medicine Tian Hua Fen, regulated immune response...

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Bibliographic Details
Main Authors: Jie Shu, Kefan Wang, Yuting Liu, Jie Zhang, Xuping Ding, Hanxiao Sun, Jiaoxiang Wu, Biao Huang, Ju Qiu, Huiming Sheng, Liming Lu
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Heliyon
Subjects:
Tian hua fen
Trichosanthin(TCS)
Type 1 diabetes mellitus
Myeloid-derived suppressor cells
Advanced glycation end product receptor
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844023101150

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http://www.sciencedirect.com/science/article/pii/S2405844023101150

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