Effect of mRNA-LNP components of two globally-marketed COVID-19 vaccines on efficacy and stability

Abstract During the COVID-19 pandemic, Pfizer-BioNTech and Moderna successfully developed nucleoside-modified mRNA lipid nanoparticle (LNP) vaccines. SARS-CoV-2 spike protein expressed by those vaccines are identical in amino acid sequence, but several key components are distinct. Here, we compared...

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Bibliographic Details
Main Authors: Lizhou Zhang, Kunal R. More, Amrita Ojha, Cody B. Jackson, Brian D. Quinlan, Hao Li, Wenhui He, Michael Farzan, Norbert Pardi, Hyeryun Choe
Format: Article
Language:English
Published: Nature Portfolio 2023-10-01
Series:npj Vaccines
Online Access:https://doi.org/10.1038/s41541-023-00751-6