Targeting Metabolism as a Platform for Inducing Allograft Tolerance in the Absence of Long-Term Immunosuppression

Targeting Metabolism as a Platform for Inducing Allograft Tolerance in the Absence of Long-Term Immunosuppression

Transplant tolerance in the absence of long-term immunosuppression has been an elusive goal for solid organ transplantation. Recently, it has become clear that metabolic reprogramming plays a critical role in promoting T cell activation, differentiation, and function. Targeting metabolism can prefer...

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Bibliographic Details
Main Authors: Chih-Hsien Cheng, Chen-Fang Lee, Byoung Chol Oh, Georg J. Furtmüller, Chirag H. Patel, Gerald Brandacher, Jonathan D. Powell
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Immunology
Subjects:
mouse
model
transplantation
immunology
metabolism
costimulation blockade
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00572/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.00572/full

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